Article
Liquid biopsy epigenomic profiling for cancer subtyping.
Nature medicine - 1 Nov 2023
Baca Sylvan C, Seo Ji-Heui, Davidsohn Matthew P, Fortunato Brad, Semaan Karl, Sotudian Shahabbedin, Lakshminarayanan Gitanjali, Diossy Miklos, Qiu Xintao, El Zarif Talal, Savignano Hunter, Canniff John, Madueke Ikenna, Saliby Renee Maria, Zhang Ziwei, Li Rong, Jiang Yijia, Taing Len, Awad Mark, Chau Cindy H, DeCaprio James A, Figg William D, Greten Tim F, Hata Aaron N, Hodi F Stephen, Hughes Melissa E, Ligon Keith L, Lin Nancy, Ng Kimmie, Oser Matthew G, Meador Catherine, Parsons Heather A, Pomerantz Mark M, Rajan Arun, Ritz Jerome, Thakuria Manisha, Tolaney Sara M, Wen Patrick Y, Long Henry, Berchuck Jacob E, Szallasi Zoltan, Choueiri Toni K, Freedman Matthew L
Abstract excerpt
Although circulating tumor DNA (ctDNA) assays are increasingly used to inform clinical decisions in cancer care, they have limited ability to identify the transcriptional programs that govern cancer phenotypes and their dynamic changes during the course of disease. To address these limitations, we developed a method for comprehensive epigenomic profiling of cancer from 1 ml of patient plasma. Using an...
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