Article

ATAC-seq Guided Interpretable Machine Learning Reveals Cancer-Specific Chromatin Features in Cell-free DNA

2025-01-13

Abstract excerpt

<title>Abstract</title> <p>Cell-free DNAs (cfDNAs) are DNA fragments found in blood. In healthy individuals, cfDNAs are primarily derived from immune cells, while in cancer patients, a significant fraction of cfDNAs originates from cancerous cells. These cancer-derived cfDNAs contain specific mutations, making cfDNA analysis a promising diagnostic biomarker. Recent studies have revealed that epigenetic informatio...

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Literature Corpus work: 20e49c82-a534-55fe-b829-fdba515aef10
DOI: 10.21203/rs.3.rs-5485170/v1

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