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Article

CUL-2LRR-1 and UBXN-3 drive replisome disassembly during DNA replication termination and mitosis.

Nature cell biology - 1 May 2017

Sonneville Remi, Moreno Sara Priego, Knebel Axel, Johnson Clare, Hastie C James, Gartner Anton, Gambus Agnieszka, Labib Karim

Abstract excerpt

Replisome disassembly is the final step of DNA replication in eukaryotes, involving the ubiquitylation and CDC48-dependent dissolution of the CMG helicase (CDC45-MCM-GINS). Using Caenorhabditis elegans early embryos and Xenopus laevis egg extracts, we show that the E3 ligase CUL-2LRR-1 associates with the replisome and drives ubiquitylation and disassembly of CMG, together with the CDC-48 cofactors UFD-1 and...

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Source

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Identifiers

PMID: 28368371
DOI: 10.1038/ncb3500
PMCID: PMC5410169

Genes

CDC45
CUL2
FAF1
NPL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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