Article

Blm Helicase Facilitates Rapid Replication of Repetitive DNA Sequences in early <i>Drosophila</i> Development

2021-06-16

Abstract excerpt

<h4>ABSTRACT</h4> The absence of functional BLM DNA helicase, a member of the RecQ family of helicases, is responsible for the rare human disorder Bloom Syndrome, which results in developmental abnormalities, DNA repair defects, genomic instability, and a predisposition to cancer. In Drosophila melanogaster , the orthologous Blm protein is essential during early development when the embryo is under the control o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3386c28a-4dbe-5f49-8dd9-306d09efcf18
DOI: 10.1101/2021.06.16.448677

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Blm Helicase Facilitates Rapid Replication of Repetitive DNA Sequences in early <i>Drosophila</i> DevelopmentDOI 10.1101/2021.06.16.448677Read

Bloom syndrome helicase contributes to germ line development and longevity in zebrafishSemantic proximity Read

Functions of the Bloom Syndrome Helicase N-terminal Intrinsically Disordered RegionSemantic proximity Read

Multiple functions of Drosophila BLM helicase in maintenance of genome stability.Semantic proximity Read

Mammalian BLM helicase is critical for integrating multiple pathways of meiotic recombination.Semantic proximity Read

Genetic control of mitotic-to-meiotic transition regulates germline cell survivalSemantic proximity Read

Loss of the bloom syndrome helicase increases DNA ligase 4-independent genome rearrangements and tumorigenesis in aging Drosophila.Semantic proximity Read

RecQ helicases: guardian angels of the DNA replication fork.Semantic proximity Read

Formation of deletions during double-strand break repair in Drosophila DmBlm mutants occurs after strand invasion.Semantic proximity Read

A novel cell-cycle-regulated interaction of the Bloom syndrome helicase BLM with Mcm6 controls replication-linked processes.Semantic proximity Read

Bloom helicase is involved in DNA surveillance in early S phase in vertebrate cells.Semantic proximity Read

Stage-specific apoptosis, developmental delay, and embryonic lethality in mice homozygous for a targeted disruption in the murine Bloom's syndrome gene.Semantic proximity Read

An <i>In Vivo</i> Analysis of the Functional Motifs of DEAD-box RNA Helicase Me31B in <i>Drosophila</i> Fertility and Germline DevelopmentSemantic proximity Read