Article

Characterization of enhancer activity in early human neurodevelopment using Massively parallel reporter assay (MPRA) and forebrain organoids

2023-08-14

Abstract excerpt

<h4> A bstract </h4> Regulation of gene expression through enhancers is one of the major processes shaping the structure and function of the human brain during development. High-throughput assays have predicted thousands of enhancers involved in neurodevelopment, and confirming their activity through orthogonal functional assays is crucial. Here, we utilized Massively Parallel Reporter Assays (MPRAs) in stem ce...

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Literature Corpus work: df693071-ffc4-5bfc-bb0a-ef62657264de
DOI: 10.1101/2023.08.14.553170

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