Article

Comprehensive network modeling approaches unravel dynamic enhancer-promoter interactions across neural differentiation

2024-05-23

Abstract excerpt

<h4>Background</h4> Increasing evidence suggests that a substantial proportion of disease-associated mutations occur in enhancers, regions of non-coding DNA essential to gene regulation. Understanding the structures and mechanisms of regulatory programs this variation affects can shed light on the apparatuses of human diseases. <h4>Results</h4> We collected epigenetic and gene expression datasets from seven earl...

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Literature Corpus work: 4116df6b-494d-5f17-a1e3-904afff81a97
DOI: 10.1101/2024.05.22.595375

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