Article

Micronuclear collapse under oxidative stress drives amphisome-mediated export of DNA in Parkinson’s disease

2025-12-02

Abstract excerpt

The diversity of extracellular vesicle (EV) subpopulations and their impact on intercellular communication are increasingly recognized, but how organelle dysfunction shapes EV content in neurodegenerative diseases remains unclear. Mitochondrial and lysosomal functional defects are hallmarks of Parkinson’s disease (PD). Here we uncover a novel pathway linking this dysfunctional axis to EV remodeling and immune acti...

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Literature Corpus work: d6f4d7f9-3cb3-5387-b239-19c5d14bacf0
DOI: 10.64898/2025.11.30.691376

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