Article

A genome-wide screen for ER autophagy highlights key roles of mitochondrial metabolism and ER-resident UFMylation

2019-02-25

Abstract excerpt

<h4>Summary</h4> Selective degradation of organelles via autophagy is critical for cellular differentiation, homeostasis, and organismal health. Autophagy of the ER (ER-phagy) is implicated in human neuropathy but is poorly understood beyond a few specialized autophagosomal receptors and remodelers. Using an ER-phagy reporter and genome-wide CRISPRi screening, we identified 200 high-confidence factors involved in...

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Literature Corpus work: c9e4304a-12b3-5981-80d8-15bbee8c1d50
DOI: 10.1101/561001

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