Article

Aftiphilin regulation of myosin light chain kinase activity promotes actin dynamics and intestinal epithelial barrier function

2022-03-16

Abstract excerpt

The expression levels of aftiphilin (AFTPH) are significantly lower in inflamed colonic tissues from patients with ulcerative colitis (UC) and mice with experimental colitis. During colonic inflammation, the selective permeability of the colonic epithelium is compromised largely due to dysregulation of proteins associated with either the tight junction (TJ) complex and actin-myosin contraction rings. Here, we hypo...

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Literature Corpus work: df34145b-4da6-53a4-b021-81ecd9e1f8aa
DOI: 10.1101/2022.03.15.484511

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