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Article

Involvement of afadin in barrier function and homeostasis of mouse intestinal epithelia.

Journal of cell science - 1 Jul 2011

Tanaka-Okamoto Miki, Hori Keiko, Ishizaki Hiroyoshi, Itoh Yu, Onishi Sachiko, Yonemura Shigenobu, Takai Yoshimi, Miyoshi Jun

Abstract excerpt

Afadin interacts with the cytoplasmic region of nectins, which are immunoglobulin-like cell adhesion molecules at adherens junctions, and links them to the actin cytoskeleton. Afadin regulates activities of cells in culture such as directional motility, proliferation and survival. We used Cre-loxP technology to generate mice conditionally lacking afadin specifically in the intestinal epithelia after birth. The...

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Identifiers

PMID: 21652626
DOI: 10.1242/jcs.081000
PMCID: PMC3115770

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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