Article

F-actin dynamics couples sphingolipid metabolism to epithelial barrier integrity in chronic colitis

2026-01-23

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Intestinal barrier dysfunction is a hallmark of inflammatory bowel diseases (IBD). This condition causes intoxication and immune hyperactivation. Understanding the events underlying epithelial barrier disruption during chronic inflammation is key to developing barrier-restoring therapies. Filamentous actin (F-actin) is essential for maintaining polarity and junctional integr...

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Literature Corpus work: 5725a6df-90a4-589f-bf24-6121c35d8c84
DOI: 10.64898/2026.01.21.700747

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