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Keratins in colorectal epithelial function and disease

13 Sept 2012

Abstract excerpt

Keratins are the largest subgroup of intermediate filament proteins, which are an important constituent of the cellular cytoskeleton. The principally expressed keratins (K) of the intestinal epithelium are K8, K18 and K19. The specific keratin profile of a particular epithelium provides it with strength and integrity. In the colon, keratins have been shown to regulate electrolyte transport, likely by targeting...

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PMID: 22974212
DOI: 10.1111/j.1365-2613.2012.00830.x

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