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Article

Keratin-8-deficient mice develop chronic spontaneous Th2 colitis amenable to antibiotic treatment.

Journal of cell science - 1 May 2005

Habtezion Aida, Toivola Diana M, Butcher Eugene C, Omary M Bishr

Abstract excerpt

Keratin 8 (K8) is the major intermediate filament protein present in intestinal epithelia. Depending on the mouse genetic background, absence of K8 causes embryonic lethality or colonic hyperplasia and colitis. We studied disease progression, the inflammatory responses, and role of luminal bacteria in K8-null mice in order to characterize the intestinal pathology of K8-associated colitis. Colon lymphocytes were...

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Identifiers

PMID: 15840656
DOI: 10.1242/jcs.02316

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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