Article

BECLIN-1 is Essential for the Maintenance of Gastrointestinal Epithelial Integrity by Regulating Endocytic Trafficking, F-actin Organization and Lysosomal Function

2024-12-02

Abstract excerpt

<h4>ABSTRACT</h4> Disrupted intestinal homeostasis and barrier function are key contributors to the development of various diseases, including inflammatory bowel disease (IBD). BECLIN-1, a core component of two class III phosphatidylinositol 3-kinase (PtdIns3K) complexes, has a dual role in autophagy and endocytic trafficking. Emerging evidence suggests it is involved in maintaining intestinal integrity which inv...

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Literature Corpus work: 78d9f5a7-7f83-58e2-b25f-470a6aac282e
DOI: 10.1101/2024.11.28.625769

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