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Article

Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer.

Biochimica et biophysica acta - 1 Mar 2014

Sun Ting Ting, Wang Yan, Cheng Hong, Xiao Hu Zhang, Xiang Juan Juan, Zhang Jie Ting, Yu Siu Bun Sydney, Martin Tracey Amanda, Ye Lin, Tsang Lai Ling, Jiang Wen Guo, Xiaohua Jiang, Chan Hsiao Chang

Abstract excerpt

How mutations or dysfunction of CFTR may increase the risk of malignancies in various tissues remains an open question. Here we report the interaction between CFTR and an adherens junction molecule, AF-6/afadin, and its involvement in the development of colon cancer. We have found that CFTR and AF-6/afadin are co-localized at the cell-cell contacts and physically interact with each other in colon cancer cell...

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Identifiers

PMID: 24373847
DOI: 10.1016/j.bbamcr.2013.12.013

Genes

CFTR

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Disrupted interaction between CFTR and AF-6/afadin aggravates malignant phenotypes of colon cancer.PMID 24373847Read ↗

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