Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

JAM-A regulates permeability and inflammation in the intestine in vivo.

The Journal of experimental medicine - 24 Dec 2007

Laukoetter Mike G, Nava Porfirio, Lee Winston Y, Severson Eric A, Capaldo Christopher T, Babbin Brian A, Williams Ifor R, Koval Michael, Peatman Eric, Campbell Jacquelyn A, Dermody Terence S, Nusrat Asma, Parkos Charles A

Abstract excerpt

Recent evidence has linked intestinal permeability to mucosal inflammation, but molecular studies are lacking. Candidate regulatory molecules localized within the tight junction (TJ) include Junctional Adhesion Molecule (JAM-A), which has been implicated in the regulation of barrier function and leukocyte migration. Thus, we analyzed the intestinal mucosa of JAM-A-deficient (JAM-A(-/-)) mice for evidence of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules
Share to Colon

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Epithelium

Share to Inflammation

Share to Intestinal Mucosa

Share to Neutrophils

Share to Permeability

Share to Receptors, Cell Surface

Source

Open in PubMed Open full text

Identifiers

PMID: 18039951
DOI: 10.1084/jem.20071416
PMCID: PMC2150975

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

JAM-A regulates permeability and inflammation in the intestine in vivo.PMID 18039951Read ↗

Targeting Opposing Immunological Roles of the Junctional Adhesion Molecule-A in Autoimmunity and CancerSemantic proximity Read ↗

MicroRNA 29 targets nuclear factor-κB-repressing factor and Claudin 1 to increase intestinal permeability.Semantic proximity Read ↗

The Roles of Junctional Adhesion Molecules (JAMs) in Cell MigrationSemantic proximity Read ↗

The Colonic Mucosal MicroRNAs, MicroRNA-219a-5p, and MicroRNA-338-3p Are Downregulated in Irritable Bowel Syndrome and Are Associated With Barrier Function and MAPK SignalingSemantic proximity Read ↗

Identification and Validation of JAM-A as a Novel Prognostic and Immune Factor in Human TumorsSemantic proximity Read ↗

Loss of polarity protein Par3 in the intestinal epithelium promotes colitis‐associated colorectal cancer progression by damaging tight junction assemblySemantic proximity Read ↗

Pyrin Inflammasome Regulates Tight Junction Integrity to Restrict Colitis and Tumorigenesis.Semantic proximity Read ↗

Exploiting the Zonulin Mouse Model to Establish the Role of Primary Impaired Gut Barrier Function on Microbiota Composition and Immune ProfilesSemantic proximity Read ↗

Increased susceptibility to colitis-associated cancer of mice lacking TIR8, an inhibitory member of the interleukin-1 receptor family.Semantic proximity Read ↗

Deletion of JAM-A causes morphological defects in the corneal epithelium.Semantic proximity Read ↗

IQ Motif-Containing GTPase-Activating Protein 2 (IQGAP2) Is a Novel Regulator of Colonic Inflammation in MiceSemantic proximity Read ↗

GPR4 Deficiency Alleviates Intestinal Inflammation in a Mouse Model of Inflammatory Bowel DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.