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Article

High-throughput CRISPRi and CRISPRa technologies in 3D genome regulation for neuropsychiatric diseases.

Human molecular genetics - 20 Oct 2022

Jones Ian R, Ren Xingjie, Shen Yin

Abstract excerpt

Advances in genomics have led to the identification of many risk loci with hundreds of genes and thousands of DNA variants associated with neuropsychiatric disorders. A significant barrier to understanding the genetic underpinnings of complex diseases is the lack of functional characterization of risk genes and variants in biological systems relevant to human health and connecting disease-associated variants to...

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PMID: 35972825
DOI: 10.1093/hmg/ddac193
PMCID: PMC9585669

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