Article
A versatile CRISPR toolbox to study neurological Ca <sub>V</sub> 3.2 channelopathies by promoter-mediated transcription control
2021-03-20
Abstract excerpt
Precise genome editing in combination with viral delivery systems provides a valuable tool for neuroscience research. Traditionally, the role of genes in neuronal circuits has been addressed by overexpression or knock-out/knock-down systems. However, those techniques do not manipulate the endogenous loci and therefore have limitations. Those constraints include that many genes exhibit extensive alternative splicin...
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Identifiers and source
- Literature Corpus work
- a2e35490-8126-56e4-8011-d209f72d3bec
- DOI
- 10.1101/2021.03.20.436250