Article

<i>In vivo</i> CRISPRa decreases seizures and rescues cognitive deficits in a rodent model of epilepsy

2018-09-29

Abstract excerpt

Epilepsy is a major health burden, calling for new mechanistic and therapeutic insights. CRISPR–mediated gene editing shows promise to cure genetic pathologies, although hitherto it has mostly been applied ex-vivo . Its translational potential for treating non-genetic pathologies is still unexplored. Furthermore, neurological diseases represent an important challenge for the application of CRISPR, because of the...

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Literature Corpus work: 4dd073a4-b6e6-58d3-bfcb-f041b96c7963
DOI: 10.1101/431015

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