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Life course plasma metabolomic signatures of genetic liability to Alzheimer's disease.

Scientific reports - 16 Feb 2024

Compton Hannah, Smith Madeleine L, Bull Caroline, Korologou-Linden Roxanna, Ben-Shlomo Yoav, Bell Joshua A, Williams Dylan M, Anderson Emma L

Abstract excerpt

Mechanisms through which most known Alzheimer's disease (AD) loci operate to increase AD risk remain unclear. Although Apolipoprotein E (APOE) is known to regulate lipid homeostasis, the effects of broader AD genetic liability on non-lipid metabolites remain unknown, and the earliest ages at which metabolic perturbations occur and how these change over time are yet to be elucidated. We examined the effects of AD...

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PMID: 38365930
DOI: 10.1038/s41598-024-54569-w
PMCID: PMC10873397

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