Article
Early Metabolic Features of Genetic Liability to Type 2 Diabetes: Cohort Study With Repeated Metabolomics Across Early Life.
Diabetes care - 1 Jul 2020
Bell Joshua A, Bull Caroline J, Gunter Marc J, Carslake David, Mahajan Anubha, Davey Smith George, Timpson Nicholas J, Vincent Emma E
Abstract excerpt
OBJECTIVE: Type 2 diabetes develops for many years before diagnosis. We aimed to reveal early metabolic features characterizing liability to adult disease by examining genetic liability to adult type 2 diabetes in relation to metabolomic traits across early life. RESEARCH DESIGN AND METHODS: Up to 4,761 offspring from the Avon Longitudinal Study of Parents and Children were studied. Linear models were used to...
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