Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alzheimer's disease polygenic risk's association with all-cause dementia through the plasma metabolome in the UK Biobank study.

GeroScience - 1 Dec 2025

Beydoun May A, Hu Yi-Han, Li Zhiguang, Georgescu Michael F, Beydoun Hind A, Noren Hooten Nicole, Walker Keenan A, Bouhrara Mustapha, Launer Lenore J, Evans Michele K, Zonderman Alan B

Abstract excerpt

Dementia, with Alzheimer's Disease (AD) accounting for 60-70% of its occurrences, is a multifactorial disorder marked by cognitive and functional decline. Polygenic risk scores (PRS) stratify genetic risk for complex diseases, including AD. Integrating PRS with metabolomics offers a pathway to better understand AD etiology and identify biomarkers for early detection. We explored the association between AD PRS,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Biological Specimen Banks

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dementia

Share to Metabolome

Share to Metabolomics

Share to Multifactorial Inheritance

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 40588577
DOI: 10.1007/s11357-025-01724-4
PMCID: PMC12638481

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alzheimer's disease polygenic risk's association with all-cause dementia through the plasma metabolome in the UK Biobank study.PMID 40588577Read ↗

Alzheimer's Disease polygenic risk, the plasma proteome, and dementia incidence among UK older adults.Semantic proximity Read ↗

Higher plasma omega-6 fatty acids are associated with lower dementia risk: evidence from NMR metabolomics and Alzheimer's disease polygenic risk in the UK Biobank.Semantic proximity Read ↗

Circulating Metabolites are Linked to Dementia and Brain Imaging Phenotypes, and Mediate Modifiable Risk PathwaysSemantic proximity Read ↗

Medical risk factors, ApoE haplotype, and Alzheimer’s disease: a large-scale analysisSemantic proximity Read ↗

Genetic versus Modifiable Risk: Predicting Dementia, Cognition, and Brain Structure in the UK BiobankSemantic proximity Read ↗

Interplay of genetic predisposition, plasma metabolome and Mediterranean diet in dementia risk and cognitive function.Semantic proximity Read ↗

Multi-Omics Integration of Transcriptomics and Metabolomics with Machine Learning Uncovers Novel Risk Factors for Alzheimer’s diseaseSemantic proximity Read ↗

The causes and consequences of Alzheimer’s disease: phenome-wide evidence from Mendelian randomizationSemantic proximity Read ↗

Metabolomic ageing (MileAge) in mid-life predicts incident vascular, unspecified and all-cause dementia.Semantic proximity Read ↗

Age- and sex-specific modifiable risk factor profiles of dementia: evidence from the UK BiobankSemantic proximity Read ↗

A phenome-wide hunt for risk factors of Alzheimer's disease: from metabolic clues to neuroimaging evidence.Semantic proximity Read ↗

Novel Plasma Proteins Associated With Alzheimer’s Disease Risk in APOE ε4 Carriers and Non-carriersSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.