Article

Genetic Regulation of the Metabolome Differs by Sex, Alzheimer’s Disease Stage, and Plasma Biomarker Status

2025-02-27

Abstract excerpt

We investigated genetic regulators of circulating plasma metabolites to identify pathways underlying biochemical changes in clinical and biomarker-assisted diagnosis of Alzheimer’s disease (AD). We computed metabolite quantitative trait loci by using whole genome sequencing and small molecule plasma metabolites from 229 older adults with clinical AD and 322 age-matched healthy controls. Unbiased associations betwe...

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Literature Corpus work: 3432bb0c-45a9-5876-893d-fda61092a386
DOI: 10.1101/2025.02.26.25322932

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