Article
Genetic regulation of the metabolome differs by sex, Alzheimer's disease stage, and plasma biomarker status.
Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Nov 2025
Eissman Jaclyn M, Qiao Min, Kalia Vrinda, Zerlin-Esteves Marielba, Reyes-Dumeyer Dolly, Piriz Angel, Dubey Saurabh, Nandakumar Renu, Lee Annie J, Lantigua Rafael A, Medrano Martin, Mejia Diones Rivera, Honig Lawrence S, Dalgard Clifton L, Miller Gary W, Mayeux Richard, Vardarajan Badri N
Abstract excerpt
INTRODUCTION: We investigated genetic regulators of circulating plasma metabolites to identify pathways underlying biochemical changes in clinical and biomarker-supported Alzheimer's disease (AD). METHODS: We computed metabolite quantitative trait loci (QTL) with whole-genome sequencing (WGS) and small molecule plasma metabolites from 229 older adults with clinical AD and 322 age-matched healthy controls....
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