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Article

The causes and consequences of Alzheimer's disease: phenome-wide evidence from Mendelian randomization.

Nature communications - 11 Aug 2022

Korologou-Linden Roxanna, Bhatta Laxmi, Brumpton Ben M, Howe Laura D, Millard Louise A C, Kolaric Katarina, Ben-Shlomo Yoav, Williams Dylan M, Smith George Davey, Anderson Emma L, Stergiakouli Evie, Davies Neil M

Abstract excerpt

Alzheimer's disease (AD) has no proven causal and modifiable risk factors, or effective interventions. We report a phenome-wide association study (PheWAS) of genetic liability for AD in 334,968 participants of the UK Biobank study, stratified by age. We also examined the effects of AD genetic liability on previously implicated risk factors. We replicated these analyses in the HUNT study. PheWAS hits and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 35953482
DOI: 10.1038/s41467-022-32183-6
PMCID: PMC9372151

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