Article

Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

2022-09-19

Abstract excerpt

<title>Abstract</title> <p><bold>Background & Aims:</bold> Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification. <bold>Methods</bold>: To assess the combined impact of the PRS and other main factors on CRC risk, 163,516 individuals from the UK Biobank were stratified as follows: 1. carriers stat...

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Literature Corpus work: defe409e-df71-5045-be87-6a6d93d94202
DOI: 10.21203/rs.3.rs-2048693/v1

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