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Polygenic Score Complements Family History and Lynch Syndrome Genes for Predicting Colorectal Cancer Risk

1 Jul 2025

Abstract excerpt

PURPOSE Family history (FH) and pathogenic variants (PVs) in Lynch syndrome (LS) genes are established risk factors of colorectal cancer (CRC). This study evaluates whether newly published polygenic scores (PGSs) improve CRC prediction of known risk factors. METHODS The associations of CRC risk with FH, PVs in LS genes ( MSH2 , MLH1 , MSH6 , PMS2 ), and PGS were investigated in the UK Biobank (UKB) using...

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PMID: 40601893
DOI: 10.1200/po-25-00081

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