Article

Clinically relevant combined effect of polygenic background, rare pathogenic germline variants, and family history on colorectal cancer incidence

2022-01-21

Abstract excerpt

<h4>Background and aims</h4> Summarised in polygenic risk scores (PRS), the effect of common, low penetrant genetic variants associated with colorectal cancer (CRC), can be used for risk stratification. <h4>Methods</h4> To assess the combined impact of the PRS and other main factors on CRC risk, 163,516 individuals from the UK Biobank were stratified as follows: 1. carriers status for germline pathogenic variant...

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Literature Corpus work: a8952139-41a7-5d73-9658-fb50784cb083
DOI: 10.1101/2022.01.20.22269585

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