Article

Ability of a polygenic risk score to refine colorectal cancer risk in Lynch syndrome

2023-04-26

Abstract excerpt

<h4>ABSTRACT</h4> <h4>Background</h4> Polygenic risk scores (PRS) have been used to stratify colorectal cancer (CRC) risk in the general population, whereas its role in Lynch syndrome (LS), the most common type of hereditary CRC, is still conflicting. We aimed to assess the ability of PRS to refine CRC risk prediction in European-descendant LS individuals. <h4>Methods</h4> 1,465 LS individuals (557 MLH1 , 517 MSH2...

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Literature Corpus work: fea17062-1ff6-598b-9bde-2b0b6db878f5
DOI: 10.1101/2023.04.20.23288850

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