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Article

Variation in the risk of colorectal cancer in families with Lynch syndrome: a retrospective cohort study.

The Lancet. Oncology - 1 Jul 2021

Abstract excerpt

BACKGROUND: Existing clinical practice guidelines for carriers of pathogenic variants of DNA mismatch repair genes (Lynch syndrome) are based on the mean age-specific cumulative risk (penetrance) of colorectal cancer for all carriers of pathogenic variants in the same gene. We aimed to estimate the variation in the penetrance of colorectal cancer between carriers of pathogenic variants in the same gene by sex and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 34111421
DOI: 10.1016/S1470-2045(21)00189-3
PMCID: PMC8934577

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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