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Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with <i>PIK3CA</i> genotype in breast cancer

2020-07-09

Abstract excerpt

<h4>ABSTRACT</h4> A PI3Kα-selective inhibitor has recently been approved for use in breast tumours harbouring mutations in PIK3CA , the gene encoding PI3Kα. Preclinical studies have suggested that the PI3K/AKT/mTORC1 signalling pathway influences stemness, a dedifferentiation-related cellular phenotype associated with aggressive cancer. No direct evidence for such a correlation has been demonstrated to date in h...

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Literature Corpus work
203cfcbf-cf16-5e4a-9563-996626299ef7
DOI
10.1101/2020.07.09.195974
Open publication

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Transcriptomically-inferred PI3K activity and stemness show a counterintuitive correlation with <i>PIK3CA</i> genotype in breast cancerDOI 10.1101/2020.07.09.195974
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