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Article

Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.

PloS one - 1 Jan 2012

Tikoo Anjali, Roh Vincent, Montgomery Karen G, Ivetac Ivan, Waring Paul, Pelzer Rebecca, Hare Lauren, Shackleton Mark, Humbert Patrick, Phillips Wayne A

Abstract excerpt

PIK3CA, the gene coding for the p110α subunit of phosphoinositide 3-kinase, is frequently mutated in a variety of human tumors including breast cancers. To better understand the role of mutant PIK3CA in the initiation and/or progression of breast cancer, we have generated mice with a conditional knock-in of the common activating mutation, Pik3ca(H1047R), into one allele of the endogenous gene in the mammary...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Gene Knock-In Techniques

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Share to Mammary Glands, Animal

Share to Mammary Neoplasms, Experimental

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Identifiers

PMID: 22666336
DOI: 10.1371/journal.pone.0036924
PMCID: PMC3364244

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Physiological levels of Pik3ca(H1047R) mutation in the mouse mammary gland results in ductal hyperplasia and formation of ERα-positive tumors.PMID 22666336Read ↗

Expression of PIK3CA mutant E545K in the mammary gland induces heterogeneous tumors but is less potent than mutant H1047RSemantic proximity Read ↗

Luminal expression of PIK3CA mutant H1047R in the mammary gland induces heterogeneous tumors.Semantic proximity Read ↗

Conditional activation of Pik3ca(H1047R) in a knock-in mouse model promotes mammary tumorigenesis and emergence of mutations.Semantic proximity Read ↗

Physiological expression of the PI3K-activating mutation Pik3ca(H1047R) combines with Apc loss to promote development of invasive intestinal adenocarcinomas in mice.Semantic proximity Read ↗

Heterozygous expression of the oncogenic Pik3ca(H1047R) mutation during murine development results in fatal embryonic and extraembryonic defects.Semantic proximity Read ↗

Physiological expression of PI3K H1047R mutation reveals its anti-metastatic potential in ErbB2-driven breast cancer.Semantic proximity Read ↗

Reactivation of multipotency by oncogenic PIK3CA induces breast tumour heterogeneity.Semantic proximity Read ↗

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PIK3CA mutations in breast cancer: reconciling findings from preclinical and clinical data.Semantic proximity Read ↗

An activating Pik3ca mutation coupled with Pten loss is sufficient to initiate ovarian tumorigenesis in mice.Semantic proximity Read ↗

Ubiquitous expression of the Pik3caH1047R mutation promotes hypoglycemia, hypoinsulinemia, and organomegaly.Semantic proximity Read ↗

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