Article

Concurrent <i>PIK3CA</i> mutant drives cachexia through inflammatory signaling in <i>EGFR</i> mutant lung cancer

2025-01-21

Abstract excerpt

PIK3CA mutation is frequently concurrent with known oncogenic drivers such as EGFR mutation in lung cancer, raising an interesting question about its real function. Cachexia is a systemic disease involving complex interaction between primary tumors and distant organs, significantly contributing to cancer-related mortality. Through integrative study of genetically engineered mouse models (GEMMs) and clinical data,...

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Literature Corpus work: 585b96aa-2ab7-59bf-ad54-49e395277c0d
DOI: 10.1101/2025.01.17.633515

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