Article

Oncogenic <i>PIK3CA</i> corrupts growth factor signaling specificity

2023-12-23

Abstract excerpt

Pathological activation of the PI3K/AKT pathway is among the most frequent defects in human cancer and is also the cause of rare overgrowth disorders. Yet, there is currently no systematic understanding of the quantitative flow of information within PI3K/AKT signaling and how it is perturbed by disease-causing mutations. Here, we develop scalable, single-cell approaches for systematic analyses of signal processing...

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Literature Corpus work: 3e2a1528-4e2c-56db-888f-e1fdcc60c8f1
DOI: 10.1101/2023.12.23.573207

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