Article

Lymphatic Malformations with Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases

2025-04-04

Abstract excerpt

<h4>ABSTRACT</h4> <h4>BACKGROUND</h4> Lymphatic malformations (LMs) are lesions due to inherited or somatic mutations that lead to a defective lymphatic vasculature. Activating KRAS mutations have been identified recently in LM patients with lymphedema, chylous ascites, or life-threatening chylothorax. In a LM mouse model, KRAS mutations are associated with a loss of lymphatic valves, which has been proposed to...

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Literature Corpus work: ded7cf16-fb8c-58f3-b64c-d201a536397c
DOI: 10.1101/2025.04.02.646922

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