Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies.

doi:10.1161/CIRCRESAHA.121.318142

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Article

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies.

Circulation research - 25 Jun 2021

Mäkinen Taija, Boon Laurence M, Vikkula Miikka, Alitalo Kari

Abstract excerpt

Lymphatic vessels maintain tissue fluid homeostasis by returning to blood circulation interstitial fluid that has extravasated from the blood capillaries. They provide a trafficking route for cells of the immune system, thus critically contributing to immune surveillance. Developmental or functional defects in the lymphatic vessels, their obstruction or damage, lead to accumulation of fluid in tissues, resulting...

Topics

Animals
Disease Models, Animal
Genetic Predisposition to Disease
Humans
Lymphangiogenesis
Lymphatic Abnormalities
Lymphatic Vessels
Mutation
Phenotype
Signal Transduction

Source

Open in PubMed

Identifiers

PMID: 34166072
DOI: 10.1161/CIRCRESAHA.121.318142

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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