Article

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformations

2022-05-22

Abstract excerpt

Vascular malformations are congenital, chronically debilitating diseases. Somatic oncogenic mutations in PIK3CA , encoding p110α-PI3K, specifically cause venous and lymphatic malformations (LM), yet the basis of vessel type-restricted disease manifestation is unknown. Here we report endothelial subtype-specific responses to the common causative Pik3ca H1047R mutation, and reveal a new immunoregulatory subtype o...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: cfc7e480-d1cb-5271-a600-dc970653dc1e
DOI: 10.1101/2022.05.22.492950

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Immunoregulatory subtype of dermal lymphatic endothelial cells at capillary terminals drives lymphatic malformationsDOI 10.1101/2022.05.22.492950Read

Constitutively active PIK3CA mutations are expressed by lymphatic and vascular endothelial cells in capillary lymphatic venous malformation.Semantic proximity Read

Lymphatic vessel: Origin, heterogeneity, biological functions and therapeutic targetsSemantic proximity Read

A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels.Semantic proximity Read

Developmental and pathological lymphangiogenesis: from models to human diseaseSemantic proximity Read

Activating PIK3CA alleles and lymphangiogenic phenotype of lymphatic endothelial cells isolated from lymphatic malformations.Semantic proximity Read

Blockade of VEGF-C signaling inhibits lymphatic malformations driven by oncogenic PIK3CA mutation.Semantic proximity Read

Lymphatic Malformations: Genetics, Mechanisms and Therapeutic Strategies.Semantic proximity Read

Somatic activating <i>BRAF</i> variants cause isolated lymphatic malformationsSemantic proximity Read

Angiopoietin–TIE2 feedforward circuit promotes PIK3CA-driven venous malformationsSemantic proximity Read

Genetic and Molecular Determinants of Lymphatic Malformations: Potential Targets for TherapySemantic proximity Read

Organ‐specific lymphangiectasia, arrested lymphatic sprouting, and maturation defects resulting from gene‐targeting of the PI3K regulatory isoforms p85α, p55α, and p50αSemantic proximity Read

Lymphatic Vasculature DevelopmentSemantic proximity Read