Hyperactive KRAS/MAPK signaling disrupts normal lymphatic vessel architecture and function

Abstract excerpt

Complex lymphatic anomalies (CLAs) are sporadically occurring diseases caused by the maldevelopment of lymphatic vessels. We and others recently reported that somatic activating mutations in KRAS can cause CLAs. However, the mechanisms by which activating KRAS mutations cause CLAs are poorly understood. Here, we show that KRAS G12D expression in lymphatic endothelial cells (LECs) during embryonic development...

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