Article
Multiple mouse models of primary lymphedema exhibit distinct defects in lymphovenous valve development.
Developmental biology - 1 Jan 2016
Geng Xin, Cha Boksik, Mahamud Md Riaj, Lim Kim-Chew, Silasi-Mansat Robert, Uddin Mohammad K M, Miura Naoyuki, Xia Lijun, Simon Alexander M, Engel James Douglas, Chen Hong, Lupu Florea, Srinivasan R Sathish
Abstract excerpt
Lymph is returned to the blood circulation exclusively via four lymphovenous valves (LVVs). Despite their vital importance, the architecture and development of LVVs is poorly understood. We analyzed the formation of LVVs at the molecular and ultrastructural levels during mouse embryogenesis and identified three critical steps. First, LVV-forming endothelial cells (LVV-ECs) differentiate from PROX1(+) progenitors...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.