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Article

Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases.

Arteriosclerosis, thrombosis, and vascular biology - 1 May 2026

Mastrogiacomo Diandra M, Price Abbigail, Fu Yuting, Banerjee Richa, Knauer Luz A, Li Kunyu, Yang Ying, Davis George E, Dellinger Michael T, Scallan Joshua P

Abstract excerpt

BACKGROUND: Lymphatic malformations are lesions that can be due to inherited or somatic mutations, and they lead to a defective lymphatic vasculature. Activating KRAS (Kirsten rat sarcoma viral oncogene homolog) mutations have been identified recently in patients with lymphatic malformation with lymphedema, chylous ascites, or life-threatening chylothorax. In a lymphatic malformation mouse model, KRAS mutations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41884898
DOI: 10.1161/ATVBAHA.126.324257
PMCID: PMC13099156

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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Lymphatic Malformations With Activating KRAS Mutations Impair Lymphatic Valve Development Through Matrix Metalloproteinases.PMID 41884898Read ↗

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