RAS-PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies.

doi:10.1242/dmm.052932

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RAS-PI3Kα signaling regulates KrasG12D-induced lymphangiogenesis in complex lymphatic anomalies.

Disease models & mechanisms - 1 Aug 2026

Fernandes Lorenzo M, Tresemer Jeffrey, Vallejo Angelica, Yao Alice, Scallan Joshua P, Dellinger Michael T

Abstract excerpt

Complex lymphatic anomalies (CLAs) are rare diseases characterized by the abnormal development of lymphatic vessels. CLAs can be caused by somatic activating variants in KRAS (e.g. KRASG12D), which stimulate MAPK and PI3K signaling. Although KRAS-MAPK signaling is known to play a critical role in CLA pathogenesis, the contribution of KRAS-PI3Kα signaling remains unclear. To investigate the role of RAS activation...

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Class I Phosphatidylinositol 3-Kinases
Endothelial Cells
Enzyme Activation
Lymphangiogenesis
Lymphatic Vessels
Phosphatidylinositol 3-Kinases

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Proto-Oncogene Proteins p21(ras)

ras Proteins

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Open in PubMed

Identifiers

PMID: 42528282
DOI: 10.1242/dmm.052932

Genes

KRAS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.