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Article

A single-cell atlas of normal and KRASG12D-malformed lymphatic vessels.

JCI insight - 28 Jan 2025

Fernandes Lorenzo M, Griswold-Wheeler Danielle, Tresemer Jeffrey D, Vallejo Angelica, Vishlaghi Neda, Levi Benjamin, Shapiro Abigail, Scallan Joshua P, Dellinger Michael T

Abstract excerpt

Somatic activating mutations in KRAS can cause complex lymphatic anomalies (CLAs). However, the specific processes that drive KRAS-mediated CLAs have yet to be fully elucidated. Here, we used single-cell RNA sequencing to construct an atlas of normal and KrasG12D-malformed lymphatic vessels. We identified 6 subtypes of lymphatic endothelial cells (LECs) in the lungs of adult wild-type mice (Ptx3, capillary,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39874106
DOI: 10.1172/jci.insight.185181
PMCID: PMC11949019

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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