Article

Multivalent Tau-Fyn interactions cooperatively arrest postsynaptic density condensate dynamics

2026-07-17

Abstract excerpt

Tau-Fyn signaling at postsynaptic sites is implicated in synaptic dysfunction and neuronal hyperexcitability in Alzheimer’s disease and related tauopathies, yet the molecular mechanisms by which Tau-Fyn interactions influence postsynaptic signaling assemblies remain poorly understood. Here, we reconstitute biomolecular condensates and membrane-associated assemblies that mimic the postsynaptic density (PSD) to inve...

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Literature Corpus work: deb0c478-84d9-5b23-b4f2-fde0396f746d
DOI: 10.64898/2026.07.16.739052

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