Synaptotagmin-1 undergoes phase separation to regulate its calcium-sensitive oligomerization.

doi:10.1083/jcb.202311191

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Article

Synaptotagmin-1 undergoes phase separation to regulate its calcium-sensitive oligomerization.

The Journal of cell biology - 7 Oct 2024

Zhu Min, Xu Han, Jin Yulei, Kong Xiaoxu, Xu Bingkuan, Liu Yinghui, Yu Haijia

Abstract excerpt

Synaptotagmin-1 (Syt1) is a calcium sensor that regulates synaptic vesicle fusion in synchronous neurotransmitter release. Syt1 interacts with negatively charged lipids and the SNARE complex to control the fusion event. However, it remains incompletely understood how Syt1 mediates Ca2+-trigged synaptic vesicle fusion. Here, we discovered that Syt1 undergoes liquid-liquid phase separation (LLPS) to form...

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Share to Adaptor Proteins, Vesicular Transport
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Identifiers

PMID: 38980206
DOI: 10.1083/jcb.202311191
PMCID: PMC11232894

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