Article

Tau hyperphosphorylation impairs cooperative binding to microtubules and perturbs organelle trafficking in neurons

2025-07-31

Abstract excerpt

Tau, a neuronal microtubule-associated protein (MAP), organizes the axonal cytoskeleton and regulates intracellular transport. Tau hyperphosphorylation is linked to neurodegeneration in tauopathies including Alzheimer’s disease. Tau binds microtubules cooperatively to form cohesive envelopes, which are thought to control access to the microtubule lattice and regulate the activity of motor proteins and other microt...

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Literature Corpus work: daa594aa-32c2-56f0-953d-b313e07a83f6
DOI: 10.1101/2025.07.31.667882

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