Article

Disease-linked mutations dysregulate neuronal condensate physical properties, composition, and RNA translation

2024-11-03

Abstract excerpt

Local RNA translation is essential for development. In neurons, deficient local translation linked with mutations in scaffold proteins results in dysregulated dendrite and dendritic spine growth. However, mechanisms by which these proteins control translation and how disease-linked mutations induce aberrant translation were unclear. We use biochemical reconstitution and neuronal assays to show that mutations to th...

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Literature Corpus work: 1e36e297-8864-5baf-90d0-9c037e2ddb87
DOI: 10.1101/2024.11.01.621623

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