Article

An electrostatic relay connects client binding and liquid-liquid phase separation of tau

2026-01-23

Abstract excerpt

Intrinsically disordered proteins (IDPs) achieve functional specificity through dynamic, multivalent interactions that are often reorganized during liquid–liquid phase separation (LLPS). How LLPS reshapes IDP conformational landscapes and binding preferences remains poorly understood. Here, we combine native ion mobility mass spectrometry, mass photometry, fluorescence microscopy, and computational modeling to dis...

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Literature Corpus work: 62d21daa-39ed-53a8-892b-4219c43be1d3
DOI: 10.64898/2026.01.21.700558

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