Article

Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy

2025-07-06

Abstract excerpt

<h4>SUMMARY</h4> Neurodegenerative disease is marked not just by loss of proteins or cells, but by dynamic rewiring of macromolecular interaction networks that precede and drive pathology. Here, we present the first temporally resolved, systems-scale map of multi-protein complex remodeling in a tauopathy model, integrating co-fractionation mass spectrometry, quantitative phosphoproteomics, and machine learning to...

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Literature Corpus work: 453d4b64-b48f-54e6-ade4-deffacd06185
DOI: 10.1101/2025.07.05.663296

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