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MONTE enables unified pan-cancer tumor purity estimation and methylation correction from bulk DNA methylation arrays

2026-01-23

Abstract excerpt

Bulk DNA methylation profiling is widely used to study cancer epigenomics in clinical settings, but these measurements aggregate signals from malignant and non-malignant cells, introducing composition-dependent confounding that complicates tumor-intrinsic interpretation and cross-cohort analyses. While existing methods can estimate tumor purity and, in some cases, correct methylation measurements, they typically r...

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Literature Corpus work: 193bb4c9-1816-5e13-a87f-a1e17d7ab0e4
DOI: 10.64898/2026.01.22.701164

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