Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancer

29 Sept 2022

Abstract excerpt

Early cancer detection by cell-free DNA faces multiple challenges: low fraction of tumor cell-free DNA, molecular heterogeneity of cancer, and sample sizes that are not sufficient to reflect diverse patient populations. Here, we develop a cancer detection approach to address these challenges. It consists of an assay, cfMethyl-Seq, for cost-effective sequencing of the cell-free DNA methylome (with > 12-fold...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Epigenetics and DNA Methylation
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36175411
DOI: 10.1038/s41467-022-32995-6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Cost-effective methylome sequencing of cell-free DNA for accurately detecting and locating cancerPMID 36175411Read ↗

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNASemantic proximity Read ↗

A Novel Tissue-Free Method to Estimate Tumor-Derived Cell-Free DNA Quantity Using Tumor Methylation PatternsSemantic proximity Read ↗

Cell-free DNA approaches for cancer early detection and interception.Semantic proximity Read ↗

GUIDE: a prospective cohort study for blood-based early detection of gastrointestinal cancers using targeted DNA methylation and fragmentomics sequencingSemantic proximity Read ↗

Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNASemantic proximity Read ↗

Single-molecule genome-wide mutation profiles of cell-free DNA for non-invasive detection of cancer.Semantic proximity Read ↗

Detection of ovarian cancer using plasma cell-free DNA methylomesSemantic proximity Read ↗

Improved circulating tumor DNA profiling by simultaneous extraction of DNA methylation and copy number information from Methylated DNA Sequencing data (MeD-seq)Semantic proximity Read ↗

Heatrich-BS enables efficient CpG enrichment and highly scalable cell-free DNA methylation profilingSemantic proximity Read ↗

cfMIND: A read-level methylation framework for accurate non-invasive disease detection using cell-free DNASemantic proximity Read ↗

Knowledge-informed multimodal cfDNA analysis improves sensitivity and generalization in cancer detectionSemantic proximity Read ↗

MetDecode: methylation-based deconvolution of cell-free DNA for noninvasive multi-cancer typingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.